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The graphic below depicts how specific triggers can lead to certain clinical manifestations, symptoms, and ultimately, autoimmunity

Obesity SURMOUNT-1 Trial In adults with obesity (without diabetes): Tirzepatide (15 mg) : 20.9% average body weight reduction over 72 weeks Semaglutide (2.4 mg) (based on STEP trials): ~14.9% average reduction STEP 5 Long-Term Results Semaglutide also demonstrated durable effects: At 104 weeks, patients maintained ~15% weight loss on semaglutide 2.4 mg (STEP 5) SELECT Trial Cardiovascular Benefit Semaglutide significantly reduced major adverse cardiovascular events by 20% in people with obesity and pre-existing heart diseaseindicating benefit beyond weight loss

Low Energy You may notice a drop in your overall energy levels or feel less stable during the day

Understanding it well means holding two things in mind at once: a genuinely novel and mechanistically interesting pharmacology, and an evidence base that is still maturing