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The article describes warm environments and fluctuating conditions with light exposure as accelerating potency loss, and refrigeration as the condition that best limits degradation over the long term

It inhibits tyrosinase, scavenges free radicals, and skews melanogenesis from the darker eumelanin to the lighter phaeomelanin, along with excellent tolerance both following oral and topical application

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The complex was then concentrated using an Amicon Ultra Centrifugal Filter (MWCO, 100 kDa) and subjected to size-exclusion chromatography (SEC) on a Superdex 200 Increase 10/300 column (GE Healthcare) that was pre-equilibrated with 20mM HEPES pH 7.4, 100mM NaCl, 2mM MgCl 2 , 1M peptide, 0.01% (w/v) LMNG and 0.0006% (w/v) CHS to separate complex from contaminants