retatrutide phase 2 trial obesity nejm 2023 triple agonist peptide Original Article: Triple–Hormone-Receptor Agonist Retatrutide

This approach requires twice the syringe preparation but may dramatically improve tolerability for patients who experience a predictable pattern of post-injection nausea followed by waning effect before the next dose

+ 70 % Collagen Synthesis vs 50% vitamin C and 40% retinoic acid in comparative in vitro models 4 000+ Genoa Gene Expression 31.2% of the human genome modulated: 1,942 genes activated, 762 deleted, 47 DNA repair genes 30 - 50 % Hair follicles Increased hair follicle size documented in hair studies 401.91 Da Molecular Weight GHK + Cu complex CAS 89030-95-5 | Formula CHNOCu -55.8 % Wrinkle Volume 12-week, double-blind, placebo-controlled facial study (71 women) Mechanism of Action Multi-Path Regeneration Epigenetic modulation, collagen synthesis and copper transport Primary Pathway Gene Expression Epigenetic Modulation GHK-Cu modulates the expression of over 4,000 human genes (31.2% of the genome)

This process continues throughout the proliferative phase, which lasts for several weeks

doi:10.4103/sjg.sjg_12_21 51