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Three studies were judged to present some concerns for risk of bias, primarily related to small sample sizes, incomplete outcome data, or early termination of follow-up ( 3.2 Sensitivity analysis Excluding the study judged to be at high risk of bias ( 4 Discussion This systemic review and meta-analysis compiled the only available studies that directly evaluated the effect of antioxidant interventions on the incidence of AMS under hypobaric hypoxia conditions in human studies

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The antioxidant action of N -acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid