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In the Phase 2 obesity trial it produced about 24% weight loss at 12 mg over 48 weeks, the most of any drug in the class, and it cut liver fat by 86% in the people who started with fatty liver. In the 80-week Phase 3 obesity trial of 2,300 adults with an average BMI of 40, 12 mg produced 28% weight loss and 9 mg reached 26%
As for the stopper, its sealing ability gets compromised
Ongoing studies continue to evaluate its role in metabolic signaling networks, peptide-receptor dynamics, and neuroendocrine communication pathways under controlled conditions
Normal serum MMA levels are typically thought to be less than 270 nmol/l in apparently healthy people, but theres little evidence of direct harm for amounts even twice as high as 270 nmol/l
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