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Table of Contents Introduction and Development History Molecular Structure and Chemistry Detailed Mechanism of Action Scientific Research Review Comparison with Related Incretin Agonists Safety Profile and Pharmacology Research Applications References Disclaimer Introduction and Development History The Incretin Imbalance Hypothesis The development of tirzepatide originated from a fundamental reconsideration of incretin biology

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reviewed thirty-five phase 3 randomized clinical trials with over 20,000 patients and did not find an increased incidence in all-cause mortality, major adverse cardiovascular events and venous thromboembolism in patients on these medications compared to patients in placebo or active comparator groups

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