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aurantiifolia are likely linked to both cardiodepressive and vasorelaxation effects through the endothelium-dependent synthesis of NO (245)

Pharmacoepidemiol Drug Saf 2010;19:1159-65

A recent investigation revealed that the expression of VRK2 was upregulated in response to ROS signals, while the link between VRK2 and metabolic rewiring remains obscure [18].In this study, we tried to explore the effects of VRK2 on the rewiring of metabolic networks and identify metabolic vulnerabilities resulting from VRK2-driven metabolic reprogramming

Both drugs share common, generally mild-to-moderate gastrointestinal side effects (nausea, vomiting, diarrhea) common to all incretin-based therapies