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More recently, glutathione-based chemical peel has also gained popularity.[] GLUTATHIONE AS A MESOTHERAPY Though there is lack of literature regarding the efficacy and methodology of use of glutathione as mesotherapy solution, it is widely being practiced by the dermatologists for treatment of melasma either as monotherapy or along with ascorbic acid, pyruvic acid, vitamin E, etc.[] TRANSDERMAL DELIVERY To enhance the permeability and reduce the foul odor associated with the topical applications of glutathione, Lee et al