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Patients were monitored for 60 min after infusion for adverse effects and instructed to contact the research staff if delayed adverse effects were suspected

BPC-157 is a signaling peptide that upregulates growth factors involved in tissue repair, particularly VEGF (new blood vessel formation), fibroblast activity (collagen production), and nitric oxide signaling

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This design choice introduces potential bias, particularly for subjective outcomes, but it reflects the practical reality that these treatments have different injection devices and titration schedules that would make blinding extremely difficult