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A blockage of SDH activity causes an accumulation of succinate, which then acts as an oncometabolite by activating signaling pathways, DNA hypermethylation, increase of reactive oxygen species (ROS) production, epithelial-to-mesenchymal transition (EMT), hypoxia-inducible factor (HIF)-1 stabilization, protein modification (such as succinylation) to sustain cancer progression (Fig

Expected 12-month results include 15 to 20% body weight loss (35 to 55 pounds for a 250-pound person), 4 to 6 inch waist circumference reduction, dramatic improvement in body shape and clothing fit, and substantial improvement in metabolic health markers

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