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For example, in head-to-head trials, patients on the highest dose of Zepbound lost up to 22.5% of their body weight over 72 weeks, while those taking semaglutide GLP-1 (Wegovy) lost about 15% over a similar period

Safety and Tolerability: What to Expect Both medications share similar side effect profiles, primarily gastrointestinal in nature: Nausea (typically most common) Diarrhea or constipation Decreased appetite Occasional vomiting Research indicates that the incidence of gastrointestinal side effects is comparable between the two medications

Both medications require gradual dose escalation and consistent weekly dosing to be effective and well-tolerated

These check-ins include reviewing weight loss progress, tracking any side effects, and addressing any concerns that may arise