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Researchers have administered doses hundreds of times higher than typical human protocols without observing toxic effects

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Similarly, a 2014 feeding study conducted in Ithaca, NY (USA) in which all participants (pregnant [N=26], lactating [N=28], and nonpregnant/nonlactating [N=21] women, ages 21-40 years), consumed a mixed diet with a known amount of biotin (average daily intake, 57 g biotin/day), reported that urinary 3-HIA excretion was higher in pregnant compared to nonpregnant women, while urinary biotin and bisnorbiotin (BNB) excretion did not differ between the groups (21)

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