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Results: Nausea, vomiting, diarrhea, and constipation were the most frequently reported GI adverse events, generally dose-dependent and transient

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Herbert V, Drivas G, Manusselis C, Mackler B, Eng J, Schwartz E

In another study evaluating the potential of Pinoresinol-4- O --d-glucopyranoside (Pgu) using the lithium/pilocarpine-induced rat model, seizure induction caused an increase in the levels of malondialdehyde (MDA) a marker of oxidative lipid damageand decreased catalase activity, while also increasing the expression levels of PTGS2, all of which was reversed by Pgu pretreatment, which also mitigated neurodegeneration 47