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In 1970, Orlowski and Meister proposed the -glutamyl cycle, which includes the synthesis, breakdown, export and import of GSH as a key process for amino acid uptake (Orlowski and Meister, 1970)

It is for this reason that glutathione may be the key treatment in most neuropathological states such as autism, neurodevelopmental disability, attention deficit disorder, neuropathy, Alzheimers disease, ALS, encephalitis and multiple sclerosis, and neurotransmitter deficiencies such as depression, anxiety, malaise and low energy (James et al., 2004

Ceramide synthases as potential targets for therapeutic intervention in human diseases