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Another long-term trial found a once-weekly injection of tirzepatide resulted in a 20% loss of body weight on average, for people who were overweight but did not have type 2 diabetes

Pulmonary Aspiration During General Anesthesia or Deep Sedation Inform patients that RYBELSUS may cause their stomach to empty more slowly which may lead to complications with anesthesia or deep sedation during planned surgeries or procedures

However, it is not recommended for those with severe liver conditions

In a mid-stage trial, nearly three-quarters of patients experienced nausea, nearly half experienced vomiting, and an much as a quarter experienced diarrhea numbers the company considered too high to convince people to take its drug twice every day