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Interestingly, the dual agonist tirzepatide has shown efficacy in neuroprotection, by counteracting hyperglycemia and insulin resistance-related effects at the neuronal level ( Also triple agonists have demonstrated to possess anti-neurodegenerative properties, indicating a potential for treating Alzheimers disease by reducing neuroinflammation and oxidative stress, enhancing neuronal health and viability, and minimizing glutamate excitotoxicity (Kopp et al., 2022)

Slides were incubated for 18 h at room temperature in anti-dsRed antibody (1:2000, TaKaRa, Cat #632393) in 0.1 M PB containing 0.3% Triton X-100 and 1% donkey serum

The average timeline to significant results is 12 to 24 weeks, with maximum results around 48 weeks