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In addition, mild to moderate adverse reactions reported include [12, 13]: Increased heart rate Headaches Diarrhea Nausea Abdominal pain Facial flushing Its important to note that the FDA has not reviewed the peptide for human use, and its safety has not been tested in large-scale clinical studies

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[12] [16] Bone mineral density assessments were not primary or secondary endpoints in the major tirzepatide trials, meaning systematic bone health monitoring was not conducted across the study populations

Statistical evaluation of the data was carried out using an unpaired t-test (plasma analytes in study 1, in vitro data), paired t-test (plasma linagliptin), two-way analysis of variance (ANOVA) with Dunnetts post-hoc test (body weight, food intake, OGTT), or KruskalWallis test (plasma analytes in study 2)