alternatives to glp 1 meds glp-1 agonists New research from @doctorsigh shows that stopping medications doesn't have mean losing progress. The study compared three next-step strategies after discontinuing treatment: lifestyle changes, switching medications, or The GLP-1 Agonists and Obesity:

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While the intense basal level of infiltrated neutrophils and the establishment of bacterial infections are primary contributors to the generation of ROS in CF, the underlying cellular dysfunction provides additional, intrinsic sources of oxidative stress

Vatanen T, Franzosa EA, Schwager R, Tripathi S, Arthur TD, Vehik K, Lernmark , Hagopian WA, Rewers MJ, She J-X, Toppari J, Ziegler A-G, Akolkar B, Krischer JP, Stewart CJ, Ajami NJ, Petrosino JF, Gevers D, Lhdesmki H, Vlamakis H, Huttenhower C, Xavier RJ (2018) The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

Abbreviations GSH: Glutathione BSO: L-buthionine-sulfoximine ROS: Reactive oxygen species GST: Glutathione S-transferase DEM: Diethyl maleate ITCs: Isothiocyanates GCL: Glutamate-cysteine ligase GPX: Glutamate peroxidases Fmoc: 9-Fluorenylmethyloxycarbonyl TOFMS: Time-of-flight mass spectrometry TEM: Transmission electron microscopy NPs: Nanoparticles PBS: Phosphate buffered saline HPLC: High-performance liquid chromatography LCMS: Liquid chromatography-mass spectrometry IC 50 : Half-maximal inhibitory concentration CLSM: Confocal laser scanning microscopy RhoB: Rhodamine B Fer-1: Ferrostatin-1 t-BuOOH: Tert-butylhydroperoxide DCFH-DA: 2,7-Dichlorodihydrofluorescein diacetate LDH: Lactate dehydrogenase ATP: Adenosine triphosphate GSDMD: Gasdermin D GSDME: Gasdermin E References Mo R, Gu Z