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Iron overload can induce profound mitochondrial dysfunction, characterized by impaired mitochondrial respiration, elevated mtROS production, mitochondrial membrane depolarization, and mitochondrial swelling [84, 85]

An important impetus to the study of alpha cell secretion of glucagon is the notion that hyperglucagonaemia and the apparently abnormal regulation of glucagon by glucose in individuals with type 2 diabetes is due to alpha cell dysfunction [23]

[72] Pharmacokinetics [edit] Taken by mouth, valproate is rapidly and virtually completely absorbed from the gut

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