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10.3390/molecules26216456 325 MitsuishiY.TaguchiK.KawataniY.ShibataT.NukiwaT.AburataniH.et al (2012)

The mechanism of this combined effect appears to be sequential: TB-500 mobilizes and migrates repair cells to the injury site (via actin regulation and chemotactic signaling), while BPC-157 creates the optimal local microenvironment (via angiogenesis, growth factor expression, and NO modulation) for those cells to perform effective repair once they arrive

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It may manifest itself as itching, eczema, urticaria, reddening of the skin, or even localized skin lesions which may progress to destruction of the skin cells (necrosis), swelling (angioedema), or allergic shock (intense generalized malaise)