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Overview GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper complex) is an endogenous tripeptide that binds copper(II) ions with high affinity and is present in human plasma at concentrations that decline markedly with age from roughly 200 ng/mL at age 20 to approximately 80 ng/mL by age 60

Smitka K, Papezova H, Vondra K, Hill M, Hainer V, Nedvidkova J (2013) The Role of Mixed Orexigenic and Anorexigenic Signals and Autoantibodies Reacting with Appetite-Regulating Neuropeptides and Peptides of the Adipose Tissue-Gut-Brain Axis: Relevance to Food Intake and Nutritional Status in Patients with Anorexia Nervosa and Bulimia Nervosa

The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium

Lower systemic inflammation : Chronic obesity is associated with elevated inflammatory markers, which have been linked to depression in multiple studies