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Funding The author(s) declare financial support was received from the Flora Miller Parill Award of the University of Texas, Southwestern Medical Center for the research, authorship, and/or publication of this article

However, the most significant risk factor for sulfonamide allergy is HIV positivity, with an incidence of approximately 27% associated with the use of trimethoprim and sulfamethoxazole (TMP-SMX) to treat pneumocystis jirovecii pneumonia (PJP)

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Eumelanin Dark brown/black pigment Strong UV absorption Protects DNA Produced mainly by olive-, tan-, and darker-skinned individuals Associated with low skin cancer risk 2