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In contrast to upstream kinases that promote JNK activation and liver injury in response to APAP, the MAPK phosphatase, which negatively regulates JNK, protects against APAP hepatotoxicity ( Jnk1 and Jnk2 deletion (Jnk hepa ) questioned the role of JNK in APAP-induced hepatotoxicity ( Jnk1 , generated by homologous recombination in ES cells and backcrossed to the C57BL/6J strain with Jnk2 -deficient mice to generate Jnk1 LoxP/LoxP / Jnk2 -/- mice

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