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In a comparison of patients with HFpEF with and without pulmonary vascular disease, exercise uncovered a distinct pathophysiology in the former group: there was impaired blood flow through the lungs, subsequent right heart congestion, and ventricular interdependence that decreased stroke volume and prevented an increase in cardiac output during exercise [79]

While some compounding pharmacies offer this combination, the lack of regulatory oversight raises concerns about dosing accuracy and contamination

However, most previous NMA studies have compared specific drugs (e.g., pioglitazone and rosiglitazone) or combinations of drug regimens (e.g., rosiglitazone+losartan, rosiglitazone+ metformin) rather than drug classes [38,39,42]

10.2337/db16-1170 13 GangjiA