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This 16-amino acid peptide is encoded within the mitochondrial genome and represents a novel class of signaling molecules that communicate between mitochondria and the nucleus to regulate whole-body metabolism

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This is often accompanied by occasional spikewave or intermittent to continuous spikewave or multi-spikewave activity, known as rhythmic high-amplitude delta with superimposed (poly)spikes (RHADS) (44)

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