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Consistently, the mRNA and protein levels of hepatic CYP8B1 were elevated, while the percentage of 12-OH BAs was increased and the proportion of non-12-OH BAs was reduced in the gallbladder bile, ileum, liver, serum, and urine in MMI mice compared to untreated control mice (CT mice) (Supplementary Fig

Results suggest orforglipron leads to significant weight loss, at an average of 7.5% of body weight over 72 weeks for those on a 6mg dose, which increased to 8.4% with 12mg and 11.2% with 36mg, compared with 2.1% with placebo

Role of halogen bonds in thyroid hormone receptor selectivity: pharmacophore-based 3D-QSSR studies

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