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Those who are allergic to Zepbound or Tirzepatide Those with type 1 diabetes Those with a family/personal history of thyroid cancer or thyroid problems People with a history of severe gastrointestinal disease Those with multiple endocrine neoplasia syndrome type 2 (MEN 2) People with disease of the pancreas (pancreatitis) Those with kidney disease Those who are pregnant or planning to become pregnant Those who are breastfeeding Speak with your medical provider before starting Zepbound if you have any of the above conditions or potential concerns