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Endocr Rev (2003) 24(5):63367

A: Functional mushrooms are species of fungi that offer measurable health and wellness benefits beyond their basic nutritional value

In DNCB-induced AD mouse models, systemic administration of the Vitamin D metabolite calcifediol markedly improved barrier function, evidenced by reduced transepidermal water loss, alleviation of stratum spinosum hyperplasia, and downregulation of the water-channel protein AQP3 [231]