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Some authors concluded that both groups with normal glucose tolerance and impaired glucose tolerance had the same relative increase in insulin levels after oral glucose, indicating an equivalent beta-cell function.[18] It seems probable that the observed effect can be induced by the incretin effect, which enhances insulin response leading to heterogeneity of insulin responses during OGTT.[19,20] In conclusion, hydroxychloroquine can effectively lower glucose levels through increase insulin level

Thus, all clinicians prescribing GLP-1s for obesity management should establish a thoughtful plan of care that includes thorough nutritional and lifestyle counseling before, during, and after the weight reduction period