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Reconstitution technique also plays a role

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Results may vary based on current mineral status and additional sources of trace minerals

Interestingly, the DNA damage repair protein RRM2, often upregulated in NB to support oncogenicity, was upregulated across all conditions, and phosphorylation at the Ser-80 and Ser-86 sites was significantly downregulated by both combinations ( Supplementary Table S1 ) ( Based on the phosphoproteomic profiling we then inferred the upstream kinases responsible for the differential phosphorylation observed in each treatment versus control, using a kinase enrichment analysis ( Figure 6 )