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doi: 10.11843/j.issn.0366-6964.2025.05.009 32 StevensC

Additionally, activated GPER can upregulate glucose transporters (GLUTs) and hexokinase (HK), increasing the level of aerobic glycolysis and leading to the accumulation of metabolic waste products, including lactic acid, which helps tumor cells evade immune surveillance and enhances their invasive capabilities [6, 34]

Adequate intracellular glutathione is therefore essential for neutralizing oxidants and preserving nitric oxide (NO) bioavailability

Pharmacodynamic-guided modified continuous reassessment method-based, dose-finding study of rapamycin in adult patients with solid tumors