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Long-Term Protocols: The most clinically relevant studies evaluated subcutaneous doses of 0.25 mg (250 mcg), 0.5 mg (500 mcg), and 1 mg (1,000 mcg) administered daily for 24 weeks
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These high correlations are consistent with the hypothesis of a mechanistic link between antioxidant and glutamatergic systems in the human brain such that under steady-state conditions, low levels of glutathione are associated with low levels of glutamatergic neurotransmission [17]
One notable exception is the observation in significant studies that NAC is highly effective in elevating glutathione under conditions where there has been a dramatic (acute depletion) drop in intracellular glutathione levels, for instance, as is the case in acetaminophen overdose
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