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Oligospermia has been reported in patients receiving systemic ketoconazole in investigational studies

Although these experiments had no effects on tumor viability, the concept was later picked up by Wilhelm Brnings 178 , 179 who combined maximally tolerable doses of insulin treatment with a KD into a de-glycation method (Entzuckerungsmethode) for the treatment of head and neck cancer patients in his clinic

It is not an approved therapy in most regions

However, in comparison with placebo or basal insulin, tirzepatide increased odds of nausea, while the doses of 10 and 15 mg were also more likely to cause vomiting or diarrhoea