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That includes: People with severe kidney disease People who are pregnant or planning to become pregnant People aged 65 and older with a history of certain conditions, such as heart disease, liver disease, coma, or diabetic ketoacidosis People who consume high amounts of alcohol each week, which constitutes 8 or more drinks for individuals assigned female at birth (typically, women) and 15 or more drinks for individuals assigned male at birth (typically men) Lastly, some medications can interact with metformin and increase your risk for severe side effects

doi: 10.1002/jsfa.8193 97 ZhangW.LiH.ZhangT.JiangB.ZhouL.MuW

A cleft lip may just affect one side of the lip or there may be 2 clefts