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Kumagai E, Hosohata K, Furumachi K, et al

The Phase 2 Obesity Trial (Jastreboff Et Al., 2023) The obesity trial published in The New England Journal of Medicine was a phase 2, double-blind, randomized study in adults with obesity (and, in a subgroup, obesity with type 2 diabetes) that assigned participants to several ascending retatrutide dose groups or placebo, with gradual dose escalation to manage tolerability, over 48 weeks

By improving metabolic health comprehensively, Retatrutide may succeed where single-target approaches fail, particularly for individuals whose mood issues have a strong metabolic component