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Research Evidence Comparison# CagriSema Research# The REDEFINE Phase 3 program provides robust evidence: REDEFINE 1 (3,417 participants, 20.4% weight loss at 68 weeks) and REDEFINE 2 (1,200 T2D participants, 13.7% weight loss)

Corneal wound closure accelerated 30-40% in treated patients

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Advanced Protocol (Weeks 5-16) CJC-1295 (no DAC) : 300 mcg before bed Ipamorelin : 300 mcg before bed Frequency : Once daily, 5 days per week Alternative : Split into morning and evening doses (150 mcg each) Duration : 12-16 weeks with careful monitoring Advanced protocols are reserved for experienced users or those with specific performance goals