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The percentage of penetrated free-DNAzymes and DNZ-NLPs to the BBB was calculated using the total area of the section of interest, accounting for the area occupied by fluorescent emitting particles, and utilizing the following formula: Statistical analysis The data were analyzed using GraphPad Prism software (version 10.0 for Windows)

Quality Controls and Pharmacy Oversight Factors Compounded medications, including both peptides where available, are prepared by licensed pharmacies based on individual prescriptions

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