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Symptoms in infancy through about age 2 years are characterized as Failure to Thrive: low muscle tone (hypotonia), poor feeding, and developmental delays

Another, larger meta-analysis reported no reduction in HF hospitalizations but did observe improvements in tissue Doppler measurements and diastolic function, suggesting possible benefits in diastolic HF [33]

Investigators are also looking at how prolonged GLP1 receptor activation might influence organs beyond the pancreas, including the heart, brain, and kidneys