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269 The benefits of TZDs in MASLD and fibrosis may be the increased adiponectin levels and the adiponectin-mediated effect on insulin sensitivity and hepatic fatty acid metabolism 270 and the downregulated fibrogenic factors and related pathways, inflammatory pathways like JAK/STAT and NF-B signaling pathways

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Going from tirzepatide to semaglutide means losing GIP receptor activation entirely