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Immediate medical attention through 999 or attendance at an emergency department is warranted if: Shortness of breath is accompanied by chest pain or pressure, particularly if radiating to the arm, jaw, or back, as this may indicate acute coronary syndrome Sudden onset of severe breathlessness with sharp chest pain, especially if associated with coughing up blood or unilateral leg swelling, could suggest pulmonary embolism Difficulty speaking in complete sentences due to breathlessness Blue discolouration of the lips or face (cyanosis) Confusion or altered consciousness Signs of severe allergic reaction such as facial swelling, throat tightness, or widespread rash developing rapidly after injection (stop Ozempic immediately) Severe abdominal pain with vomiting, fever and breathlessness (stop Ozempic if pancreatitis is suspected) Symptoms of diabetic ketoacidosis: excessive thirst, frequent urination, nausea, abdominal pain, rapid deep breathing, fruity-smelling breath, confusion (check ketones if possible) Patients should contact their GP or NHS 111 within 24 hours if they experience new or worsening shortness of breath that is persistent but not immediately life-threatening, particularly if accompanied by fever, productive cough, leg swelling, or palpitations

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Increase the Tmax (the time taken to reach maximum plasma concentration)