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It can participate in one-carbon metabolism through serine hydroxymethyltransferase (SHMT) to support nucleotide synthesis, and can also serve as a component of glutathione (GSH) in maintaining cellular redox homeostasis (66)

Ligands [edit] Agonists [edit] Non-selective [edit] -MSH -MSH -MSH ACTH Afamelanotide Bremelanotide Melanotan II Modimelanotide Setmelanotide MC4 receptor agonist which is FDA approved to help with chronic weight management in those with pathogenic (or uncertain) variants in POMC and certain related genes

Van Lint, P

Real-Life Implications: What Patients Should Know For patients like you, these alerts may provoke questions and uncertainties