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A paper published this week in JAMA Psychiatry found semaglutide, the active ingredient in GLP-1 drugs like Ozempic and Wegovy, "significantly improved" motivation in patients with major depressive disorder, or MDD a promising finding because lack of motivation and related disruptions to the brains reward pathways play a critical role in many other psychiatric conditions as well

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To modify antioxidants in therapy, strategies include targeting GPX4 activity, manipulating GSH levels, optimizing exogenous antioxidants, and exploiting Nuclear factor erythroid 2related factor 2 (NRF2) pathways [254]

Tirzepatide commonly causes constipation , diarrhea, bloating, and sometimes vomiting