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Notable Studies: Once-Weekly Semaglutide for Weight Management: A Clinical Review Effect of Oral Semaglutide Compared With Placebo and Subcutaneous Semaglutide on Glycemic Control in Patients With Type 2 Diabetes Effects of semaglutide on risk of cardiovascular events across a continuum of cardiovascular risk: combined post hoc analysis of the SUSTAIN and PIONEER trials Also Known As: Ozempic, Rybelsus, Wegovy, A10BJ06 Research Applications: Anti-obesity and weight loss Glycemic control Cardiovascular health Neuroprotection Risks: Gastrointestinal upset and related reactions Link to thyroid C-cell tumors in rodent studies Contraindicated in Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Risk of acute and chronic pancreatitis FDA approval only for T2D and overweight/obese subjects Chemical Structure What is Semaglutide

doi: 10.1016/j.molmet.2018.04.001