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Its mechanism is thought to involve interaction with apical integrins, activating downstream signalling pathways such as focal adhesion kinase and steroid receptor coactivators, resulting in TJ modulation (Hsu et al., 2012

Glucagon also contributes to energy homeostasis by promoting satiety through vagal signaling to brainstem nuclei and by increasing resting energy expenditure through facultative thermogenesis in brown adipose tissue, skeletal muscle, and through promotion of WAT browning [22]

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A major advantage of the liver model used in this study is that TVX toxicity in vascular and hepatic cell layers was clearly demonstrated independently from external LPS or TNF- stimulation