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Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation

The primary limitations identified included the absence of a list of excluded studies and justification, as well as a written or registered protocol for the included studies, a lack of detailed funding sources, an assessment of risk of bias, and a discussion regarding the heterogeneity observed

These offer enhanced patient convenience, potentially improving adherence in primary care and emerging markets

AMPK and SIRT1 are activated by an AMP and NAD + dependent mechanism and acts through regulation of phosphorylation and deacetylation of their targets, respectively