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McCrimmon RJ, Catarig AM, Frias JP, et al

Mounjaro also became available on the NHS for weight management in June 2025, though access remains highly restricted and is reserved for individuals with the greatest clinical need

alternative routes have unknown safety implications Efficacy : The dose-response relationship established in trials assumes subcutaneous delivery Tolerability : Gastrointestinal adverse effects (nausea, vomiting, diarrhea) are dose-dependent and may be affected by altered absorption Patients with lower body mass index or those injecting in areas with less subcutaneous fat may be at higher risk of inadvertent intramuscular injection if proper technique is not followed

The results from clinical trials have been so profound that it is now also approved for chronic weight management in many countries, often under a different brand name (Zepbound in the US)