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Estrogen deficiency and the decline of skin collagen were first observed in 1941 by Albright, who noticed that thin skin was more common in older women with osteoporotic fractures [21]

1.1 Glutathione peroxidase Glutathione peroxidase (GPx) an mammalian enzyme, contains selenocysteine residue in its active site, For the last four decades, an extensive research has been carried out on the mammalian antioxidant enzymes GPx [34]

More recently, a breakthrough 2026 study utilizing both in-vitro cellular models and an in-vivo human pharmacokinetic trial further solidified these findings