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Similarly, gluconeogenic enzymes (PEPCK, G6Pase) and bile acid synthetic enzymes (CYP7A1) display rhythmic expression patterns that ensure metabolic processes occur at the most suitable time of day (30, 31) (Figures 1, 2)

Retatrutide activates three receptors: GLP-1 (appetite suppression), GIP (enhanced fat metabolism and reduced nausea), and glucagon (increased energy expenditure and fat burning)

After 56 weeks: Placebo group lost 1.2% of body weight Recommended dose (7.5/46 mg) group lost 7.8% of body weight Top dose (15/92 mg) group lost 9.8% of body weight The EQUIP trial enrolled 1,267 adults with class II and III obesity (BMI 35+)

10.1007/978-3-030-56153-6_21 34 GarrelsE.KainthT.SilvaB.YadavG.GillG.SalehiM.et al (2023)