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During oxidative phosphorylation, mitochondria generate and scavenge reactive oxygen species (ROS)

Its been consistent, real results. Average weight loss in 1 year is 11-20% (vs ~2-3% with diet and exercise alone)

2 Missing data were imputed using available data according to value and timing of last available observation on treatment and endpoints baseline value from retrieved subjects (RD-MI)

In its advice published in December, PBAC noted there was a "significant risk" that people who did not meet the two criteria and particularly those who met one threshold but not the other would seek access to the subsidised drugs and therefore that a "risk sharing arrangement" with the company would be needed to manage the cost to the government