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It also improved cerebral oxidative metabolism and neurological outcomes in rats following cortical contusion injury (Fukushima et al., 2010), protected against MPTP induced degeneration of neurons and reduced oxidative stress in a mouse model of Parkinson's disease (Huh et al., 2013), and reduced cognitive deficits in a mouse model of Alzheimer's disease (Isopi et al., In the SOD1 G93A mouse model of ALS, pyruvate (1000 mg/kg/week i.p.) slowed disease progression and also improved motor symptoms in a rotarod test and survival by 10.5% when it was administered starting at the onset of disease (Park et al., 2007)

Insoluble fiber should be introduced cautiously as it may increase bloating and gas in some individuals, potentially compounding tirzepatide's gastrointestinal effects